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Sleep apnea and hypertension.
F García-Río1, M A Racionero, J M Pino
1Servicios de Neumología, Hospital Universitario La Paz, Universidad Autónoma, Madrid, Spain.
Chest
|May 16, 2000
Summary
Obstructive sleep apnea (OSA) patients showed varying responses to hypoxia, linked to blood pressure (BP) levels. Peripheral chemosensitivity may mediate the connection between OSA and hypertension.
Area of Science:
- Cardiology
- Pulmonology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) is linked to hypertension.
- The role of central inspiratory drive and chemosensitivity in this association is not fully understood.
Purpose of the Study:
- To investigate the central inspiratory drive response to hypoxia in OSA patients based on their circadian blood pressure (BP) profile.
- To explore relationships between sleep architecture, hypoxic sensitivity, urinary catecholamine excretion, and BP in OSA patients.
Main Methods:
- Simultaneous polysomnography, 24-h ambulatory BP monitoring, and urinary catecholamine analysis were performed in 24 OSA patients and 11 controls.
- OSA patients were classified into three types based on their BP patterns.
- Mouth occlusion pressure (P(0.1)) response to progressive isocapnic hypoxia was measured.
Main Results:
- A significant difference in hypoxic P(0.1) response was observed across control and OSA groups (Type 1, 2, and 3).
- In OSA patients, chemosensitivity correlated with the apnea-hypopnea index and nocturnal epinephrine excretion.
- Hypoxic response was significantly related to both diurnal and nocturnal mean BP.
Conclusions:
- Peripheral chemosensitivity may play a mediating role in the relationship between obstructive sleep apnea and hypertension.
- These findings highlight the importance of assessing chemosensitivity in OSA patients with hypertension.