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[Serotonin metabolism in the rat brain during water deprivation and hydration]
N K Popova1, L N Ivanova, T G Amstislavskaia
1Institute of Cytology and Genetics, Siberian Branch of the Russian Acad. Sci., Novosibirsk.
Abstract:
Water deprivation (WD) decreased the serotonin (5-HT) level and significantly increased the 5-hydroxyindoleacetic acid (5-HIAA) in the rat midbrain and hypothalamus, the catabolic 5-HIAA/5-HT ratio increasing three-fold. Hydration (H) produced a moderate increase in the 5-HT and 5-HIAA levels in the hypothalamus with no changes in the 5-HIAA/5-HT ratio. Hydration exerted no significant effect upon the 5-HT level and metabolism in the midbrain. A two-fold increase of corticosterone concentration in water deprivation and its decrease in hydration were shown to occur in peripheral blood plasma.