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[Opioid system and cardiac resistance to ischemic and reperfusion injuries]
Iu B Lishmanov1, L N Maslov, S V Tam
1Research Institute of Cardiology, Siberian Branch of the Russian Acad. Med. Sci., Tomsk.
Abstract:
In vivo pre-treatment with the opioid receptor antagonist D,L-naloxone completely eliminated the reperfusion-induced creatine kinase (CK) leakage from the rat isolated perfused haert. The inactive isomer L-naloxone decreased the CK release by half. The (-antagonist ICI 174,864 and k-antagonist nor-binanltorphimine exerted a weaker protective effect. The (-antagonist DAMGO, the (2-agonist DSLET, the k1-agonist spiradolin, or the sigma-agonist (+)-SKF 10047, improved myocardial cell viability after ischemia/reperfusion.