Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory B cells and CD27.

K Agematsu1

  • 1Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. agemats@gipac.shinshu-u.ac.jp

Histology and Histopathology
|May 16, 2000
PubMed
Summary
This summary is machine-generated.

B cells differentiate into memory or plasma cells after antigen activation. CD27 is a key memory marker, crucial for B cell differentiation into plasma cells, especially through T/B cell interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early-Onset Inflammatory Bowel Disease Caused by Mutations in the X-Linked Gene IL2RG.

Journal of investigational allergology & clinical immunology·2020
Same author

Comparison of serum inflammatory cytokine concentrations in familial Mediterranean fever and rheumatoid arthritis patients.

Scandinavian journal of rheumatology·2017
Same author

Analysis of Mutations in the IL2RG Gene in 2 Asian Infants With X-linked Severe Combined Immunodeficiency.

Journal of investigational allergology & clinical immunology·2015
Same author

Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease.

Infection·2015
Same author

Expression of CD64 on polymorphonuclear neutrophils in patients with familial Mediterranean fever.

Clinical and experimental immunology·2011
Same author

Femoral osteomyelitis due to Cladophialophora arxii in a patient with chronic granulomatous disease.

Infection·2009
Same journal

Isofraxidin ameliorates CCl<sub>4</sub>-induced liver fibrosis in mice by inhibiting the NF-κB pathway.

Histology and histopathology·2026
Same journal

FOXO3/HMOX1 axis promotes melanoma progression by regulating ferroptosis and immune escape.

Histology and histopathology·2026
Same journal

Immunohistochemical evaluation of CD44 expression and its correlation with clinicopathological factors and molecular markers (EGFR, STAT3, and lipid metabolism-related proteins) in oral squamous cell carcinoma.

Histology and histopathology·2026
Same journal

Betulinic acid mitigates septic cardiomyopathy in mice through modulating the TLR4/MyD88/NF-κB signaling axis and NLRP3 inflammasome pathway.

Histology and histopathology·2026
Same journal

Extension loss following ACL reconstruction: A narrative review of mechanisms and phase-specific management.

Histology and histopathology·2026
Same journal

ShenQiWan alleviates chondrocyte pyroptosis in knee osteoarthritis by inhibiting the NF-κB/NLRP3 signaling pathway.

Histology and histopathology·2026
See all related articles

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • B cell differentiation into memory or plasma cells is critical for adaptive immunity.
  • Mature B cells are classified into subtypes based on IgD and CD27 expression, including naive, memory, and plasma cell precursors.
  • CD27, a tumor necrosis factor receptor (TNFR) family member, is identified as a marker for B cell memory.

Purpose of the Study:

  • To review the differentiation pathways of mature B cells.
  • To elucidate the role of T/B cell interactions, specifically CD27/CD70 and CD40/CD154 pathways, in B cell fate.
  • To discuss the characteristics and significance of memory B cells.

Main Methods:

  • Review of existing literature on B cell subpopulations and differentiation.
  • Analysis of T/B cell interactions and their signaling pathways (CD27/CD70 vs. CD40/CD154).

Related Experiment Videos

  • Examination of B cell subtypes defined by IgD and CD27 expression.

    • Main Results:

    • CD27+ B cells exhibit characteristics of memory cells, including larger size, abundant cytoplasm, and immunoglobulin production capacity.
    • Ligation of CD27 provides essential signals that promote B cell entry into the plasma cell differentiation pathway.
    • T/B cell interactions via CD27/CD70 signaling are compared with CD40/CD154 signaling in controlling B cell differentiation.

    Conclusions:

    • CD27 is a crucial marker and signaling molecule in B cell memory development and plasma cell differentiation.
    • T/B cell interactions play a significant role in regulating B cell fate decisions.
    • Understanding these pathways is vital for comprehending humoral immunity and developing targeted therapies.