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Updated: Aug 14, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
The proinflammatory transcription factor NFkappaB: a potential target for novel therapeutical strategies
Abstract:
NFkappaB is a ubiquitous transcription factor involved in the proinflammatory response to cytokines (such as IL-1 or TNF-alpha) and some particular stresses. The unraveling of the molecular mechanisms involved in its activation is quite recent, particularly in the case of IL-1-stimulated cells, but the identification of the molecules involved in this pathway opens new prospects in both pharmacological and toxicological research.
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