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Prostate cancer: correlation between local and systemic disease.

M Marzi1, P Rosi, E Mearini

  • 1Urology Clinic University of Perugia.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology
|May 17, 2000
PubMed
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Transrectal ultrasonography (TRUS) can predict the systemic course of prostate cancer. Regular TRUS screenings may reduce the need for other routine check-ups in patients with localized prostate cancer.

Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Background:

  • Prostate cancer is a significant health concern, ranking as the second most common neoplasm in Italian men.
  • Transrectal ultrasonography (TRUS) is a cost-effective, minimally invasive, and well-tolerated imaging modality for assessing local prostate cancer status.

Purpose of the Study:

  • To determine if a detailed local ultrasonographic evaluation of prostate cancer can predict its systemic progression.
  • To assess the utility of TRUS in monitoring both local and systemic disease course.

Main Methods:

  • 136 prostate cancer outpatients treated with palliative therapy or radiotherapy were evaluated.
  • Local disease assessment included gland dimensions, lesion characteristics, capsular involvement, and surrounding structures via TRUS (longitudinal/axial scans).

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  • Follow-up duration ranged from 12 to 132 months.

    • Main Results:

    • A global concordance between local and systemic disease course was observed in 85.3% of patients (116/136).
    • Only 9.5% of patients (13/136) showed isolated systemic progression.
    • 7 patients (5.1%) exhibited local progression without systemic involvement.

    Conclusions:

    • Periodic Transrectal Ultrasonography (TRUS), performed twice yearly, reliably predicts the systemic course of prostate cancer.
    • Routine TRUS can potentially reduce the necessity for other routine check-ups, reserving them for cases with specific clinical indications.