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Chemical synthesis of cross-linked purine nucleosides
1Department of Pharmacological Sciences, State University of New York at Stony Brook, 11794-3400, USA. dericca@unisa.it
Organic Letters
|May 18, 2000
Abstract:
[reaction: see text] An efficient route to all of the possible cross-linked 2'-deoxypurines 1-3 has been developed by means of the Pd-mediated C-N bond formation in the key step. Utilizing this protocol, the synthesis of the first unnatural protected purine trimeric adduct 4 has been accomplished.