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An efficient synthesis of pyrimidines from beta-amino alcohols
C Agami1, L Dechoux, M Melaimi
1Laboratoire de Synthèse Asymétrique UMR 7611, Université P. et M. Curie, Paris, France.
Organic Letters
|May 18, 2000
Abstract:
[reaction: see text] Pyrimidinones 3 were chemoselectively reduced by using metal-catalyzed hydrogenation and stereoselectively substituted by various nucleophiles. Starting from beta-amino alcohols 1, the overall process allows efficient access to substituted pyrimidines 4 and 6.