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TTV - a virus searching for a disease.

Y Cossart1

  • 1Department of Infectious Diseases, University of Sydney, Sydney, Australia. ycossart@infdis.usyd.edu.au

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|May 18, 2000
PubMed
Summary

Transfusion-transmitted virus (TTV) is a newly identified virus found in blood donors worldwide. Its exact classification and role in disease remain under investigation.

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Area of Science:

  • Virology
  • Hepatology
  • Epidemiology

Background:

  • Transfusion-transmitted virus (TTV) was identified in patients with non-A-G post-transfusion hepatitis.
  • Previous research aimed to explain a small number of hepatitis cases not attributed to known hepatitis viruses.

Purpose of the Study:

  • To review and summarize published clinical and epidemiological data on TTV.
  • To assess the properties, natural history, and taxonomic classification of TTV.

Main Methods:

  • Initial identification used representational difference analysis to detect foreign DNA in acute illness.
  • Subsequent studies employed Polymerase Chain Reaction (PCR) to detect TTV in serum, liver, and fecal samples.
  • This review synthesizes data from international clinical and epidemiological studies.

Main Results:

  • TTV has been detected in 1-40% of healthy blood donors across various countries.
  • The virus is also present in fecal samples, indicating a potential route of transmission.
  • Current data suggests TTV is ubiquitous in the human population.

Conclusions:

  • The taxonomic classification of TTV within the parvovirus family is premature due to unknown size, light density, and lack of characteristic sequence features.
  • The prevalence of TTV in blood donors and its presence in feces highlight its widespread nature.
  • Further research is required to definitively determine TTV's taxonomic identity and its etiological role in human disease.

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