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Updated: Oct 16, 2026
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Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
Administration of endotoxin associated with lipopolysaccharide tolerance protects mice against fungal infection
N Rayhane1, C Fitting, O Lortholary
1Unité d'Immuno-Allergie, Institut Pasteur, 75015 Paris, France.
Infection and Immunity
|May 19, 2000
Abstract:
Lipopolysaccharide (LPS) pretreatment of mice resulted in a significantly enhanced survival after disseminated Cryptococcus neoformans infection. The survival was associated with reduced fungal burden in tissues. LPS-pretreated mice had lower levels of cytokines in blood, spleen, and lungs and higher levels in brain. Pentoxifylline abolished the beneficial effect of LPS pretreatment.
