Related Experiment Video
Updated: Aug 18, 2026
Establishment of an Oronasal Fistula Mice Model
Published on: September 8, 2023
[Epidermoid carcinoma developing in a chronic anal fistula]
1Service de Chirurgie générale, Hôtel-Dieu de France, Faculté de Médecine-Université Saint-Joseph, Beyrouth, Liban. abad@dm.net.lb
Background:
Malignant degeneration of anal fistula is a rare occurrence in the course of a common disease. Abdominoperineal resection offers the only hope of cure.
Case Report:
A 41-year-old patient who was operated 14 years earlier for anal fistula presented recurrence treated by fistulectomy. Histology revealed a well-differentiated squamous-cell carcinoma. Radiotherapy (45 Gy) was added postoperatively. Five months later, local recurrence was treated by chemotherapy and abdominoperineal resection. Two months later the patient died from cachexia with local recurrence.
Discussion:
Biopsies of anal fistula tract and histology of all fistulectomies are required for early diagnosis of possible carcinoma. Abdominoperineal resection offers the only hope of cure.
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