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Single-oral-dose azithromycin prophylaxis against experimental streptococcal or staphylococcal aortic valve
A Tsitsika1, A Pefanis, G S Perdikaris
1Infectious Diseases Section, 4th Department of Medicine, Sismanoglion General Hospital, Athens University School of Medicine, Athens, Greece.
Antimicrobial Agents and Chemotherapy
|May 19, 2000
Abstract:
Azithromycin and ampicillin protected 94 and 72% of animals challenged with Streptococcus oralis, respectively (P = 0.177), while azithromycin and vancomycin protected 59 and 94% of the methicillin-resistant Staphylococcus aureus (MRSA)-challenged animals, respectively (P = 0.018). Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.