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In vitro release kinetics of Tolmetin from tabletted Eudragit microparticles
R Pignatello1, P Consoli, G Puglisi
1pignatel@mbox.unict.it
Journal of Microencapsulation
|May 20, 2000
Summary
This study investigated Eudragit microparticles containing Tolmetin (a NSAID). Tablet compression and additives like MgO and magnesium stearate were explored to control drug release, with mathematical models analyzing dissolution and diffusion.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Previous work detailed Eudragit RS 100 and RL 100 microparticle preparation with Tolmetin.
- Free microparticles showed minimal impact on in vitro drug release compared to the free drug.
Purpose of the Study:
- To evaluate the effect of compression and co-additives on drug delivery from Eudragit microparticle tablets.
- To investigate the use of MgO and magnesium stearate in modifying microparticle properties and drug release.
- To mathematically analyze drug release mechanisms from microparticle tablets.
Main Methods:
- Microparticles were compressed into tablets.
- Additives including magnesium oxide (MgO) and magnesium stearate were incorporated.
- In vitro drug release studies were performed.
- Mathematical models (two semi-empirical equations) were used for analysis.
Main Results:
- Compression and co-additives influenced drug delivery from microparticle tablets.
- MgO addition aimed to reduce pH sensitivity during dissolution.
- Magnesium stearate acted as a droplet stabilizer, reducing particle size and release rate.
- Mathematical evaluation provided insights into dissolution and diffusion phenomena.
Conclusions:
- Tablet formulation significantly impacts drug release from Eudragit microparticles.
- MgO and magnesium stearate are effective in modulating drug release characteristics.
- Mathematical modeling aids in understanding the complex release kinetics from microparticle tablets.