Xanthones from Calophyllum teysmannii var. inophylloide

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Botany

Background:

• Calophyllum teysmannii Miq. var. inophylloide is a plant species found in Thailand.
• Xanthones are a class of organic compounds with diverse biological activities.
• Previous research may have identified some compounds from this plant, but further investigation is warranted.

Purpose of the Study:

• To conduct a phytochemical investigation of the wood of Calophyllum teysmannii Miq. var. inophylloide.
• To isolate and identify secondary metabolites, specifically xanthones and benzoic acid derivatives.
• To contribute to the knowledge of the chemical constituents of this Thai plant.

Main Methods:

• Extraction of secondary metabolites from the wood of Calophyllum teysmannii Miq. var. inophylloide.
• Isolation and purification of compounds using chromatographic techniques.
• Structure elucidation of isolated compounds using spectroscopic methods (e.g., NMR, MS).

Main Results:

• Isolation of three xanthones: 1,2,8-trimethoxyxanthone, 6-hydroxy-1,2,5,7-tetramethoxyxanthone, and 3-(3'-carboxybutyl)-4-methoxyxanthone (teysmannic acid).
• Identification of scriblitifolic acid, 1,7-dihydroxyxanthone, and the benzoic acid derivative leiocarpic acid.
• The study successfully identified several known and potentially novel compounds from the plant's wood.

Conclusions:

• The wood of Calophyllum teysmannii Miq. var. inophylloide is a source of various xanthone derivatives and a benzoic acid derivative.
• The identified compounds, including teysmannic acid, add to the known phytochemical profile of the Calophyllum genus.
• This research enhances the understanding of the chemical diversity within Calophyllum teysmannii Miq. var. inophylloide.