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Unexpected molecular mimicry among peptides MHC class II, blood-clotting factor X, and HIV-1 envelope glycoprotein

G H Tishkoff1, L T Hunt

  • 1Department of Medicine, Michigan State University, 48824, East Lansing, MI, USA.

Thrombosis Research
|May 24, 2000
PubMed
Abstract

No abstract available in PubMed .

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
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As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...

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