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A simple approach to DOTAP and its analogs bearing different fatty acids
U Massing1, J T Kley, L Gürtesch
1Department of Medicinal Oncology, Tumor Biology Center, Freiburg, Germany. umas@tumorbio.uni-freiburg.de
Chemistry and Physics of Lipids
|May 24, 2000
Abstract:
A simple synthesis of N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl sulfate (DOTAP) and its analogs differing in the fatty acids is presented. The synthesis is designed as quasi-one-pot reaction and the precipitating products are purified by simple recrystallization.