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Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
Legg-Calvé-Perthes disease and passive smoking
S García Mata1, E Ardanaz Aicua, A Hidalgo Ovejero
1Trauma and Orthopaedic Department, Virgen del Camino Hospital-Clínica Ubarmin, Pamplona, Spain.
Journal of Pediatric Orthopedics
|May 24, 2000
Summary
Passive smoking significantly increases the risk of Legg-Calvé-Perthes disease (LCPD) in children. Children exposed to secondhand smoke face over five times the risk of developing LCPD compared to unexposed children.
Area of Science:
- Pediatric Orthopedics
- Environmental Health
Background:
- Legg-Calvé-Perthes disease (LCPD) is a hip disorder affecting children.
- The environmental factors contributing to LCPD are not fully understood.
Purpose of the Study:
- To investigate the association between passive smoking (secondhand smoke exposure) and the incidence of Legg-Calvé-Perthes disease in children.
Main Methods:
- A case-control study was conducted with 90 children diagnosed with LCPD and 183 healthy children as controls.
- Data on passive smoking exposure, age, and gender were collected and analyzed.
Main Results:
- A significantly higher proportion of children with LCPD were exposed to passive smoking (78.9%) compared to controls (43.2%).
- After controlling for age and gender, passive smoking showed a significant association with LCPD (p = 0.0000).
- The odds ratio for LCPD in passive smokers was 5.32 (95% CI: 2.92-9.69), indicating a more than fivefold increased risk.
Conclusions:
- Passive smoking is a significant risk factor associated with Legg-Calvé-Perthes disease.
- Reducing children's exposure to secondhand smoke may help prevent LCPD.
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