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Alterations in antioxidant status during neonatal sepsis
1Department of Biochemistry, Kalawati Saran Children's Hospital, Bangla Sahib Marg, New Delhi, India. batra6@hotmail.com
Annals of Tropical Paediatrics
|May 29, 2000
Summary
Neonatal sepsis increases reactive oxygen species (ROS), indicated by elevated xanthine oxidase (XO), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Despite increased antioxidant enzymes, cellular damage and malondialdehyde (MDA) levels rise, suggesting potential benefits of antioxidant therapy.
Area of Science:
- Biochemistry
- Neonatal Medicine
- Oxidative Stress Research
Background:
- Neonatal sepsis poses a significant survival threat.
- Reactive oxygen species (ROS) are implicated in various diseases.
- Understanding antioxidant status in neonatal sepsis is crucial for treatment.
Purpose of the Study:
- To evaluate antioxidant and non-enzymatic antioxidant status in neonates with sepsis.
- To investigate the role of oxidative stress in neonatal sepsis.
- To explore the potential for antioxidant therapy in neonatal sepsis management.
Main Methods:
- Measured serum activities of xanthine oxidase (XO), creatine phosphokinase (CPK), superoxide dismutase (SOD), glutathione peroxidase (GPx), and peroxidase (PO).
- Assessed malondialdehyde (MDA) content and levels of uric acid (UA) and albumin (ALB).
- Compared biochemical markers between 30 septic neonates and 20 age-matched controls, categorized by clinical factors.
Main Results:
- Septic neonates showed significantly elevated XO, CPK, SOD, GPx, and MDA compared to controls.
- PO activity and UA, ALB levels were decreased in septic neonates.
- Specific subgroup analyses revealed variations in CPK, UA, and GPx levels based on term/preterm, onset, and shock status.
Conclusions:
- Increased ROS production is evident in neonatal sepsis, supported by elevated XO, SOD, and GPx.
- Antioxidant enzyme elevation was insufficient to prevent cellular damage, indicated by high MDA.
- Antioxidant therapy may benefit neonatal sepsis management, requiring further clinical investigation.