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Collagenous gastritis: a case report, morphologic evaluation, and review
Z Vesoulis1, G Lozanski, P Ravichandran
1Department of Pathology, Summa Health Systems, Akron, Ohio 44304, USA.
Summary
Collagenous gastritis, a rare condition, is characterized by thickened subepithelial collagen in the stomach. This case report proposes diagnostic criteria, linking it to other collagenous enterocolitides and celiac sprue.
Area of Science:
- Gastroenterology
- Pathology
- Gastrointestinal Diseases
Background:
- Collagenous gastritis is a rare condition with limited diagnostic criteria.
- Existing literature includes only four previous case reports.
- Pathologic features may overlap with other collagenous enterocolitides.
Observation:
- A case of collagenous gastritis is presented in a patient with celiac sprue and ulcerative colitis.
- Gastric biopsies showed thick subepithelial collagen bands (mean 27.07 microns) and inflammatory infiltrates.
- Comparison with controls revealed significantly higher collagen deposition in the patient.
Findings:
- Proposed diagnostic criteria for collagenous gastritis include subepithelial collagen >10 microns, lymphoplasmacytic infiltrates, intraepithelial lymphocytes, and epithelial damage.
- Cumulative data suggest a mean subepithelial collagen thickness of 36.9 microns in reported cases.
- Associated findings include chronic gastritis, epithelial damage, and potential links to celiac sprue and lymphocytic colitis.
Implications:
- Collagenous gastritis may represent a spectrum of disease with lymphocytic gastritis, celiac sprue, and collagenous colitis.
- The proposed criteria can aid in confident diagnosis of collagenous gastritis.
- Understanding this condition may improve patient diagnosis and management, particularly in those with autoimmune gastrointestinal disorders.