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Targeted chemoembolization of tumors with poly(2-hydroxyethyl methacrylate) particles
D Horák1, E Guseinov, V Vishnevskii
1Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague.
Journal of Biomedical Materials Research
|May 29, 2000
Summary
Selective embolization using poly(2-hydroxyethyl methacrylate) [poly(HEMA)] particles combined with targeted chemotherapy offers an effective tumor treatment. This chemoembolization method, involving localized drug infusion, demonstrated long-term survival in a liver carcinoid metastasis patient.
Area of Science:
- Oncology
- Interventional Radiology
- Biomaterials Science
Background:
- Tumor treatment often involves systemic therapies with significant side effects.
- Metastatic liver tumors present a therapeutic challenge, requiring localized treatment strategies.
- Poly(2-hydroxyethyl methacrylate) [poly(HEMA)] hydrogel particles offer potential for localized drug delivery.
Purpose of the Study:
- To evaluate the efficacy of chemoembolization using poly(HEMA) hydrogel particles and targeted chemotherapy for tumor treatment.
- To assess the safety and long-term outcomes of this combined therapeutic approach.
- To investigate the therapeutic mechanisms, including ischemia and localized drug infusion.
Main Methods:
- Selective embolization of tumor-feeding arteries using spherical and cylindrical poly(HEMA) particles.
- Catheter-directed infusion of chemotherapy agents (5-fluorouracil, doxorubicin) and Lipiodol into tumorous tissue.
- Concurrent anticoagulant therapy with heparin or dalteparin.
- Transcutaneous transhepatic portography and embolization, followed by hydrogel sealing of vessels.
- Surgical resection of the affected liver lobe after treatment.
Main Results:
- A patient with carcinoid liver metastases showed sustained survival for over 4 years post-treatment.
- The chemoembolization procedure resulted in effective tumor treatment with minimal systemic drug exposure.
- Therapeutic effects were attributed to induced ischemia and sustained local drug delivery.
- No significant adverse events related to the embolization procedure were noted.
Conclusions:
- Chemoembolization with poly(HEMA) hydrogel particles and targeted chemotherapy is an effective treatment for various tumors, including liver metastases.
- This approach allows for localized drug delivery, minimizing systemic toxicity and maximizing therapeutic impact.
- The combination of ischemia and slow drug infusion via embolization provides a promising strategy for oncological treatment.