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Updated: Aug 8, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: July 1, 2013
Interleukin 16: implications for CD4 functions and HIV-1 progression
D M Center1, H Kornfeld, T C Ryan
1Evans Memorial Department of Medicine, Pulmonary Center at Boston University School of Medicine, MA 02118, USA. dcenter@lung.bumc.bu.edu
Abstract:
In this article, David Center and colleagues clarify the controversies that have emerged over the unique structure of interleukin 16 and its anti-HIV-1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions.
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