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Clinical evaluation of a new high efficiency hemodialyzer: polysynthane
1Renal Division, Baxter Healthcare Corporation, McGaw Park, Illinois, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|May 29, 2000
Summary
This study evaluated a new high-efficiency dialyzer for chronic hemodialysis (HD) patients with high hematocrit and large body size. The results show this dialyzer can achieve adequate dialysis targets even for challenging patient profiles.
Area of Science:
- Nephrology
- Biomedical Engineering
Background:
- Chronic hemodialysis (HD) patients often present with high hematocrit and large body size.
- These characteristics can make achieving recommended dialysis adequacy targets challenging.
Purpose of the Study:
- To assess the efficacy of a new high-efficiency dialyzer (PSN210) in meeting dialysis adequacy targets for patients with high hematocrit and large body size.
- To evaluate the mass transfer capabilities of the PSN210 dialyzer.
Main Methods:
- Six patients with high hematocrit and large body size undergoing chronic hemodialysis were studied.
- The PSN210 dialyzer was used with prescribed blood flow of 400 ml/min and dialysate flow of 800 ml/min for 4 hours.
- Delivered urea Kt/V, urea reduction ratio (URR), and whole blood clearances for urea, creatinine, and phosphate were measured.
Main Results:
- Mean delivered urea Kt/V was 1.38 +/- 0.25, and mean URR was 0.73 +/- 0.07.
- Whole blood clearances achieved were: urea 315 +/- 13 ml/min, creatinine 246 +/- 28 ml/min, and phosphate 260 +/- 27 ml/min.
- These values indicate efficient solute removal.
Conclusions:
- The PSN210 dialyzer demonstrates an efficient mass transfer design.
- Adequate dialysis can be delivered to large-sized patients with high hematocrit using this high-efficiency dialyzer.