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Updated: Aug 3, 2026
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In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Zebrafish: a model system for the study of human disease
1Division of Hematology/Oncology, Department of Medicine, Children's Hospital, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
Current Opinion in Genetics & Development
|May 29, 2000
Summary
Zebrafish (Danio rerio) are valuable vertebrate models for studying biology and genetics. Genetic screens reveal mutations mimicking human diseases, advancing research in physiology and medicine.
Area of Science:
- Vertebrate biology
- Genetics
- Developmental biology
Background:
- Zebrafish (Danio rerio) serve as a premier model organism.
- They are highly suitable for genetic and developmental studies.
- Numerous mutant phenotypes have been identified through large-scale screens.
Purpose of the Study:
- To highlight the utility of zebrafish in biological research.
- To emphasize their role in understanding human diseases.
- To showcase advancements in zebrafish genetic and genomic resources.
Main Methods:
- Large-scale genetic screens.
- Analysis of mutant phenotypes.
- Leveraging genetic reagents and genomic data.
Main Results:
- Identification of hundreds of zebrafish mutants.
- Many mutants exhibit phenotypes similar to human clinical disorders.
- Progress in zebrafish genome sequencing and reagent development.
Conclusions:
- Zebrafish are a powerful system for studying vertebrate biology, physiology, and human disease.
- Advancements in genetic tools and genomics are enhancing zebrafish research potential.
- This model organism offers significant insights into human health and disease mechanisms.
