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Left-right axis malformations in man and mouse
1Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, 77030, USA. bcasey@bcm.tmc.edu
Current Opinion in Genetics & Development
|May 29, 2000
Abstract:
The study of left-right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left-right axis formation. Recently, the roles of the TGF-beta family, Sonic hedgehog and fibroblast growth factor signaling, homeobox genes, and cilia in left-right axis determination have been more clearly defined. The identification of genes and environmental factors affecting left-right axis formation has important implications for understanding human laterality defects.