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Serial quantitative coronary angiography and coronary events
W J Mack1, M Xiang, R H Selzer
1Atherosclerosis Research Unit, Department of Medicine, University of Southern California 90089-9010, USA. wmack@rcf.usc.edu
American Heart Journal
|May 29, 2000
Summary
Quantitative coronary angiography (QCA) lesion measures predict major cardiac events. Minimum lumen diameter changes in lesions independently predict coronary events, suggesting it
Area of Science:
- Cardiology
- Medical Imaging
- Clinical Trials
Background:
- Quantitative coronary angiography (QCA) is used to assess atherosclerosis progression.
- No prior validation studies have compared different QCA measures for predicting coronary events.
Purpose of the Study:
- To compare various QCA measures as surrogates for coronary events.
- To validate QCA measures in predicting myocardial infarction, coronary death, and revascularizations.
Main Methods:
- Analysis of coronary angiograms from 156 men in the Cholesterol Lowering Atherosclerosis Study.
- Measurement of changes in percent diameter stenosis, minimum lumen diameter, and other QCA parameters.
- Correlation of QCA changes with 12-year follow-up data on coronary events using proportional hazards models.
Main Results:
- Changes in percent diameter stenosis and minimum lumen diameter of coronary lesions significantly predicted myocardial infarction/coronary death.
- All QCA measures correlated with the risk of any coronary event.
- Change in minimum lumen diameter of lesions was the sole independent predictor of coronary events.
Conclusions:
- All QCA measures of coronary artery disease progression relate to overall coronary events.
- Only QCA measures of lesion progression predict myocardial infarction/coronary death.
- QCA measures of lesion change may serve as superior surrogate endpoints for hard coronary events compared to segment measures.