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High-resolution diffusion imaging using a radial turbo-spin-echo sequence: implementation, eddy current compensation,

M H Seifert1, P M Jakob, V Jellus

  • 1Lehrstuhl für Experimentelle Physik V, Physikalisches Institut der Universität Würzburg, Germany.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|June 1, 2000
PubMed
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This study introduces a diffusion-weighted radial turbo-spin-echo technique for high-resolution MRI. It effectively reduces motion and eddy current artifacts, enabling detailed brain imaging and anisotropy studies.

Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Neuroimaging

Background:

  • Diffusion-weighted imaging (DWI) is crucial for assessing tissue microstructure.
  • Existing DWI techniques often suffer from motion and eddy current artifacts, limiting image quality and quantitative analysis.
  • High-resolution DWI is needed for detailed studies of brain anatomy and pathology.

Purpose of the Study:

  • To develop and validate a segmented radial turbo-spin-echo (DW-rTSE) technique for high-resolution multislice DWI and quantitative ADC mapping.
  • To investigate and mitigate artifacts caused by eddy currents and pulsatile brain motion in DWI.
  • To enable in vivo DWI with high in-plane resolution without cardiac gating.

Main Methods:

  • Implementation of a segmented radial turbo-spin-echo (DW-rTSE) sequence.

Related Experiment Videos

  • Detailed analysis and compensation of eddy current artifacts using gradient timing adjustments.
  • Application of diffusion gradients in all three orthogonal directions.
  • Development of a self-navigation approach to reduce nonrigid body motion artifacts.

    • Main Results:

    • Achieved in vivo diffusion-weighted images with 700 microm in-plane resolution, largely free of bulk motion artifacts.
    • Successfully compensated for eddy current artifacts, allowing for diffusion tensor imaging and anisotropy studies.
    • Demonstrated feasibility of the DW-rTSE technique in five healthy volunteers.

    Conclusions:

    • The developed DW-rTSE technique provides high-resolution, artifact-reduced DWI and quantitative ADC mapping.
    • Effective eddy current compensation and motion reduction strategies are crucial for robust DWI.
    • This method holds promise for advanced neuroimaging applications, including the study of diffusional anisotropy.