Related Experiment Videos
New synthetic vitamin D analogs with antiproliferative activities
A Steinmeyer1, G Kirsch, G Neef
1Schering AG, Institute of Medicinal Chemistry, Berlin, D-13342, Germany. andreas.steinmeyer@schering.de
Current Pharmaceutical Design
|June 1, 2000
Abstract:
The introduction of oxygen atoms into different positions of the vitamin D side chain is described. By combining the arising 23-oxa and 25-oxa elements with other structural modifications (19-nor, iso-19-nor, 20-methyl, 20-ene, 20,21-cyclo) calcitriol analogs with remarkable levels of dissociation between beneficial acitivities on cell growth regulation and undesired hypercalcemia were identified. Structure-activity relations are elaborated in a very systematic outline of the Schering drug finding program in this particular class of vitamin D compounds.