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Cutaneous monomorphous CD4- and CD56-positive large-cell lymphoma
T Nagatani1, H Okazawa, T Kambara
1Department of Dermatology, Yokohama City University Medical Center, Yokohama, Japan. d2674@urahp.yokohama-cu.ac.jp
Dermatology (Basel, Switzerland)
|June 1, 2000
Summary
This study describes cutaneous CD4+ and CD56+ lymphoma, a rare condition primarily affecting the skin in elderly patients. The findings suggest it is distinct from other NK/T cell lymphomas, with a poor prognosis.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- CD56 (NCAM)-positive lymphomas represent a unique group.
- Previously identified subtypes include nasal NK/T cell lymphoma and aggressive NK cell leukemia/lymphoma.
Observation:
- This study focused on the clinicopathological characteristics of cutaneous CD4+ and CD56+ lymphoma.
- Four elderly patients (mean age 81.2 years) with this rare skin lymphoma were analyzed.
Findings:
- The primary manifestation was skin involvement, with disease progression involving lymphadenopathy, splenomegaly, leukemic spread, and CNS involvement.
- The mean survival time was 12.2 months, and Epstein-Barr virus was not detected in tumor cells.
- This lymphoma appears distinct from nasal NK/T cell lymphoma and aggressive NK cell leukemia/lymphoma, sharing similarities with blastic NK cell lymphoma/leukemia.
Implications:
- Clarifies the distinct clinicopathological features of cutaneous CD4+ and CD56+ lymphoma.
- Highlights the aggressive nature and poor prognosis of this rare lymphoma subtype.
- Suggests potential classification alongside blastic NK cell lymphoma/leukemia.