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Fluoroquinolones.
1Department of Medicine, Medical College of Pennsylvania, Hahnemann University, School of Medicine, Philadelphia, USA.
Infectious Disease Clinics of North America
|June 1, 2000
Summary
Newer fluoroquinolone antibiotics offer expanded antimicrobial activity but require careful use due to potential toxicities. This review details their pharmacokinetics, safety, and appropriate applications in treating various infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Microbiology
Background:
- The fluoroquinolone class of antimicrobials has seen significant expansion.
- Continued growth in this drug class is anticipated over the next decade.
Purpose of the Study:
- To provide a detailed discussion of newer fluoroquinolone agents.
- To compare newer fluoroquinolones with older agents like ciprofloxacin and ofloxacin.
- To describe safety concerns, including liver toxicity and issues with trovafloxacin.
Main Methods:
- Review of pharmacokinetics and pharmacodynamics of newer fluoroquinolones.
- Analysis of in vitro activity spectrum.
- Discussion of drug interactions and safety profiles.
- Comparison of newer agents against established fluoroquinolones.
Main Results:
- Newer fluoroquinolones exhibit a broad spectrum of in vitro activity.
- Specific safety concerns, such as liver toxicity associated with trovafloxacin, are highlighted.
- Pharmacokinetic and pharmacodynamic properties vary among newer agents.
Conclusions:
- Appropriate use of fluoroquinolones is crucial for effective treatment.
- Fluoroquinolones play a key role in managing urinary tract, sexually transmitted, gastrointestinal, bone, and respiratory tract infections.
- Understanding the nuances of newer agents is essential for optimizing patient outcomes and minimizing risks.
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