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[YKL 40: marker of disease activity in rheumatoid arthritis?]
M Morgante1, O Di Munno, D Morgante
1Istituto di Medicina Interna, Università degli Studi, Pisa.
Minerva Medica
|June 1, 2000
Abstract:
In patients with rheumatoid arthritis the serum and synovial fluid levels of a glycoprotein called YKL 40 are correlated to the severity of disease. YKL 40 may be related to disease activity in RA; it is induced by vitamine D and is reduced by TGF b. YKL 40 has been isolated from bovine mammary secretions during non lactating period and from Human osteosarcoma cell line MG-63. Some observations on experimental and clinical studies are presented.