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Fulminant hepatitis in Kala-azar.
U K Singh1, R K Sinha, V K Sharma
1Department of Pediatrics, Patna Medical College.
Indian Journal of Pediatrics
|September 1, 1995
Summary
Kala-azar can cause liver damage, including mild dysfunction and severe fulminant hepatitis. While most patients recover with treatment, some may succumb to liver failure, indicating Kala-azar as a potential cause of hepatitis.
Area of Science:
- Hepatology
- Infectious Diseases
- Tropical Medicine
Background:
- Kala-azar, a parasitic disease, is known to affect various organs.
- Hepatic involvement in Kala-azar requires further investigation to understand its spectrum and outcomes.
Purpose of the Study:
- To investigate the prevalence and severity of hepatic involvement in patients with Kala-azar.
- To determine the impact of Kala-azar on liver function and the potential for fulminant hepatitis.
Main Methods:
- A retrospective study of 150 Kala-azar cases.
- Assessment of hepatic function and clinical outcomes.
Main Results:
- Mild hepatic dysfunction was observed in 25 cases (16.7%).
- Fulminant hepatitis occurred in 3 cases (2%).
- Two cases died due to hepatic failure, despite anti-Kala-azar therapy.
Conclusions:
- Kala-azar can lead to significant hepatic compromise.
- Fulminant hepatitis is a potential, albeit rare, complication of Kala-azar.
- Prompt diagnosis and treatment are crucial for managing hepatic involvement in Kala-azar.