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Updated: Aug 11, 2026

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Published on: November 21, 2013
Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by
L de Haan1, J Lavalaye, D Linszen
1Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands. ldehaan@amc.uva.nl
Objective:
The authors' goal was to study the relationship between subjective experience during treatment with olanzapine or risperidone and dopamine D(2) receptor occupancy in stabilized patients with schizophrenia.
Method:
Subjective experience, psychopathology, and extrapyramidal symptoms were assessed, and D(2) receptor occupancy was determined with [(123)I]iodobenzamide single photon emission computed tomography, in 22 patients whose schizophrenia was stabilized by olanzapine or risperidone.
Results:
Subjective experience, depression, and negative symptoms were related to dopamine D(2) receptor occupancy, but extrapyramidal symptoms were not.
Conclusions:
These results provide preliminary evidence that negative subjective experience is related to high D(2) receptor occupancy. Longitudinal study is required because this relationship may have implications for dosing strategies.
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