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Caloric restriction and aging: an update.

E J Masoro1

  • 1Department of Physiology, University of Texas Health Science Center at San Antonio, 78284-7756, TX, USA. masoro@aol.com

Experimental Gerontology
|June 1, 2000
PubMed
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Caloric restriction (CR), reducing food intake by 30-50%, extends lifespan and delays aging in rodents. This review explores the biological mechanisms, including reduced oxidative damage and improved metabolic health, behind CR's antiaging effects.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Metabolism

Background:

  • Caloric restriction (CR) in rodents significantly increases longevity and delays age-related decline.
  • CR involves reducing food intake to 50-70% of ad libitum levels.
  • The antiaging effects are attributed to reduced calorie intake.

Purpose of the Study:

  • To explore the biological mechanisms underlying the antiaging effects of caloric restriction.
  • To examine the roles of oxidative damage, glycemia, insulinemia, and hormesis in CR's longevity benefits.
  • To present a unified scenario of CR's antiaging action based on evolutionary considerations.

Main Methods:

  • Review of existing literature on caloric restriction and aging.
  • In-depth analysis of proposed mechanisms: oxidative stress, glucose/insulin metabolism, and hormesis.

Related Experiment Videos

  • Consideration of the evolutionary basis of CR's antiaging effects.

    • Main Results:

    • CR attenuates oxidative damage, a key factor in aging.
    • CR modulates glycemia and insulinemia, improving metabolic health.
    • Hormesis, a stress-response mechanism, may also contribute to CR's benefits.

    Conclusions:

    • CR's antiaging effects are multifaceted, involving reduced oxidative stress, improved metabolic regulation, and hormetic responses.
    • An evolutionary perspective supports the adaptive nature of CR's longevity-promoting actions.
    • A unified model integrating these mechanisms provides a comprehensive understanding of CR's antiaging potential.