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Related Experiment Videos

Physiology of aging.

E J Masoro1

  • 1Aging Research and Education Center, Department of Physiology, University of Texas Health Science Center, San Antonio 78229-3900, USA.

International Journal of Sport Nutrition and Exercise Metabolism
|March 28, 2002
PubMed
Summary

Physiological aging involves deterioration, often influenced by age-associated diseases and gene-environment interactions. Understanding normal aging requires accounting for these complex factors and individual variations.

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Area of Science:

  • Gerontology
  • Physiology
  • Genetics

Background:

  • Physiological deterioration is common in adult aging.
  • Studies on aging are complicated by factors unrelated to aging itself.
  • Age-associated diseases significantly contribute to physiological decline.

Purpose of the Study:

  • To clarify the complexities in interpreting aging studies.
  • To highlight the role of age-associated disease in physiological deterioration.
  • To emphasize the impact of gene-environment interactions on aging.

Main Methods:

  • Review of cross-sectional and longitudinal aging studies.
  • Analysis of factors confounding aging research.
  • Consideration of disease-free subjects in
  • normal
  • aging studies.

Main Results:

  • Age-associated disease is a primary driver of physiological deterioration.
  • Excluding disease in studies of
  • normal
  • aging overlooks a key aspect of the aging process.
  • Gene-environment interactions are increasingly recognized as crucial in age-related decline.

Conclusions:

  • Age-associated disease is an integral and common component of aging.
  • Individual variability in aging rates and deterioration is significant.
  • Future research must account for disease and genetic factors in aging.

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