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Related Experiment Videos

Electrohepatogram in pathologic liver conditions.

A Shafik1

  • 1Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt. shafisci@link.com.eg

Frontiers in Bioscience : a Journal and Virtual Library
|June 2, 2000
PubMed
Summary

Electrohepatography (EHG) reveals distinct electrical patterns in various liver diseases. This non-invasive technique differentiates healthy livers from those with cancer, hepatitis, or metastases, aiding in diagnosis.

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Area of Science:

  • Hepatology
  • Medical Diagnostics
  • Electrophysiology

Background:

  • The liver's electrical activity, characterized by pacesetter potentials (PPs), is crucial for its function.
  • Previous studies established the electrohepatogram (EHG) in normal canine and human livers.
  • Hepatoarrhythmic activity was observed in canine liver injury and human liver cirrhosis.

Purpose of the Study:

  • To investigate hepatic electrical activity in various liver diseases.
  • To identify distinct EHG patterns for different pathological liver conditions.
  • To evaluate EHG as a diagnostic tool for liver diseases.

Main Methods:

  • Studied 55 subjects: 10 with hepatocellular cancer, 16 with acute hepatitis, 14 with metastatic liver deposits, and 15 healthy controls.

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  • Placed three electrodes below the costal margin, 4-5 cm apart.
  • Recorded EHG for at least 20 minutes per subject using a Beckman R611 recorder.

    • Main Results:

    • Healthy volunteers showed regular, reproducible EHG rhythms.
    • Hepatocellular cancer patients exhibited 'hepatoarrhythmic' EHG patterns with irregular frequency and amplitude.
    • Acute hepatitis presented 'silent' (preicteric/icteric) or 'hepatoarrhythmic' (convalescent) patterns.
    • Metastatic liver deposits showed 'hepatoarrhythmic' (few deposits) or 'silent' (numerous deposits) patterns.
    • All observed patterns were reproducible across subjects and recordings.

    Conclusions:

    • Distinct EHG patterns correlate with specific liver diseases, reflecting liver cell function.
    • Normal EHG indicates healthy liver function, 'silent' EHG suggests non-functioning cells, and 'hepatoarrhythmia' implies impaired function.
    • Electrohepatography is a simple, non-invasive, non-radiologic method suitable for diagnosing liver diseases.