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Magnesium dynamics and relation to left ventricular function in acute myocardial infarction.
1Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Japanese Circulation Journal
|June 2, 2000
Summary
Magnesium levels shift during acute myocardial infarction (AMI), with serum magnesium increasing and erythrocyte magnesium decreasing. These changes correlate with left ventricular ejection fraction (LVEF), suggesting magnesium
Area of Science:
- Cardiology
- Biochemistry
- Medical Research
Background:
- Acute myocardial infarction (AMI) can impact electrolyte balance.
- Magnesium (Mg) plays a crucial role in cardiac function.
- Understanding Mg shifts during AMI is vital for patient outcomes.
Purpose of the Study:
- To investigate serial changes in serum and erythrocyte magnesium levels in AMI patients.
- To determine the relationship between these magnesium changes and left ventricular ejection fraction (LVEF) at one month post-infarction.
Main Methods:
- Serial measurements of serum and erythrocyte Mg in 26 AMI patients over 21 days.
- Calculation of Mg change ratios during the acute phase.
- Correlation analysis between Mg changes and LVEF at 1 month.
Main Results:
- Serum Mg levels showed a tendency to increase from day 1 to day 21 post-AMI.
- Erythrocyte Mg levels significantly decreased on days 2 and 4 compared to day 1.
- A positive correlation was found between serum Mg change and LVEF (r=0.55), and a negative correlation between erythrocyte Mg change and LVEF (r=-0.57).
Conclusions:
- An extracellular shift of magnesium occurred within the first 2 days of AMI.
- The increase in extracellular magnesium may be important for preserving left ventricular function one month after AMI.