Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Detecting bottlenecks and selective sweeps from DNA sequence polymorphism.

N Galtier1, F Depaulis, N H Barton

  • 1Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom. galtier@crit1.univ-montp2.fr

Genetics
|June 3, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One mother for two species via obligate cross-species cloning in ants.

Nature·2025
Same author

Establishment in a new habitat by polygenic adaptation.

Theoretical population biology·2017
Same author

The infinitesimal model: Definition, derivation, and implications.

Theoretical population biology·2017
Same author

A CHROMOSOMAL CLINE IN THE GRASSHOPPER PODISMA PEDESTRIS.

Evolution; international journal of organic evolution·2017
Same author

HABITAT PREFERENCE IN THE BOMBINA HYBRID ZONE IN CROATIA.

Evolution; international journal of organic evolution·2017
Same author

THE STRUCTURE OF THE HYBRID ZONE IN URODERMA BILOBATUM (CHIROPTERA: PHYLLOSTOMATIDAE).

Evolution; international journal of organic evolution·2017
Same journal

Coexistence of piRNA and KZFP defense systems: Evolutionary dynamics of layered defense against transposable elements.

Genetics·2026
Same journal

Creation and manipulation of bipartite expression transgenes in C. elegans using phiC31 recombinase.

Genetics·2026
Same journal

Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

Genetics·2026
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
See all related articles

This study introduces a new method to detect population diversity reduction and differentiate between demographic events and selective sweeps. Analysis of Drosophila melanogaster suggests recent selective sweeps, not population bottlenecks, shaped genetic variability.

Area of Science:

  • Population genetics
  • Evolutionary biology
  • Genomics

Background:

  • Recent reductions in genetic variability can stem from demographic events like bottlenecks or selective sweeps.
  • Distinguishing between these causes is crucial for understanding population history and evolutionary forces.

Purpose of the Study:

  • To develop a coalescence-based maximum-likelihood method to detect diversity-reducing events.
  • To differentiate between demographic and selective origins of reduced genetic variability.
  • To estimate the timing and strength of these events.

Main Methods:

  • A maximum-likelihood framework utilizing coalescence theory.
  • Analysis of gene genealogy shapes, which are distorted by diversity-reducing events.
  • Comparison of genetic patterns across different genomic loci to distinguish genome-wide demographic effects from localized selective effects.

Related Experiment Videos

Main Results:

  • The method can detect diversity-reducing events and distinguish their causes.
  • Gene trees exhibit a more star-like shape under diversity-reducing events compared to the standard coalescent model.
  • Application to Drosophila melanogaster sequence data indicated that a bottleneck is unlikely.

Conclusions:

  • The developed method effectively identifies and differentiates causes of reduced genetic diversity.
  • Evidence suggests one or more selective sweeps, rather than a population bottleneck, likely occurred in the recent history of the studied Drosophila melanogaster population.