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Primary nodal gastrinomas.

M E Herrmann1, M C Ciesla, G Chejfec

  • 1Department of Pathology, Loyola University Medical Center, Stritch School of Medicine, Maywood, IL 60153, USA. MHERRMA@wpo.it.luc.edu

Archives of Pathology & Laboratory Medicine
|June 3, 2000
PubMed
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Neuroendocrine cells were found in lymph nodes within the gastrinoma triangle, supporting the existence of primary nodal gastrinomas. This research investigates the presence of these cells in a specific anatomical region.

Area of Science:

  • Gastroenterology and Surgical Pathology

Background:

  • Primary lymph node gastrinoma describes gastrin-producing tumors in lymph nodes without a known primary source.
  • The gastrinoma triangle, a specific anatomical region, was hypothesized to contain neuroendocrine cells.

Purpose of the Study:

  • To investigate the presence of neuroendocrine cells in lymph nodes within the gastrinoma triangle.
  • To determine if these cells contribute to primary nodal gastrinomas.

Main Methods:

  • Immunohistochemistry was used to examine 417 lymph nodes from 20 autopsy cases in the gastrinoma triangle.
  • Antibodies to synaptophysin and gastrin were employed to detect neuroendocrine cells.
  • Findings were compared to lymph nodes from axillary and inguinal dissections.

Main Results:

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  • Synaptophysin-reactive cells were identified in 5 cases, and gastrin-reactive cells in 3 cases within the gastrinoma triangle.
  • No neuroendocrine cells were detected in axillary or inguinal lymph nodes.
  • This suggests a unique presence of neuroendocrine cells in the gastrinoma triangle.

Conclusions:

  • The study supports the hypothesis of neuroendocrine cell entrapment during development.
  • Findings indicate the potential for primary nodal gastrinomas within the gastrinoma triangle.