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Related Experiment Videos

Drug discovery in the next millennium.

E H Ohlstein1, R R Ruffolo, J D Elliott

  • 1Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939, USA. ohlstein@sbphrd.com

Annual Review of Pharmacology and Toxicology
|June 3, 2000
PubMed
Summary

High-throughput methods and bioinformatics accelerate the discovery of new molecular targets for drug development. This review outlines a critical path for future pharmaceutical research and innovation.

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Area of Science:

  • Genomics
  • Drug Discovery
  • Bioinformatics

Background:

  • Human gene sequencing has revealed numerous novel molecular targets for therapeutic drugs.
  • The pharmaceutical industry requires advanced methods to identify and validate these targets.
  • Technological advancements are essential to manage the increasing complexity of drug discovery.

Purpose of the Study:

  • To review technological advancements in high-throughput methods for drug discovery.
  • To discuss emerging fields like bioinformatics, cheminformatics, and functional genomics.
  • To outline a critical path for future drug discovery processes.

Main Methods:

  • Review of technological advances in biological and chemical assays.
  • Analysis of the role of bioinformatics and cheminformatics in target identification.

Related Experiment Videos

  • Exploration of functional genomics in validating molecular targets.

    • Main Results:

    • High-throughput screening and validation methods are crucial for novel drug targets.
    • Bioinformatics, cheminformatics, and functional genomics are essential components of modern drug discovery.
    • A clear pathway for drug discovery into the new millennium has been established.

    Conclusions:

    • The integration of advanced technologies and interdisciplinary fields is transforming drug discovery.
    • Efficient selection and validation of molecular targets are key to pharmaceutical innovation.
    • A strategic roadmap is available for navigating the future of drug development.