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Drug discovery in the next millennium
E H Ohlstein1, R R Ruffolo, J D Elliott
1Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939, USA. ohlstein@sbphrd.com
Annual Review of Pharmacology and Toxicology
|June 3, 2000
Summary
High-throughput methods and bioinformatics accelerate the discovery of new molecular targets for drug development. This review outlines a critical path for future pharmaceutical research and innovation.
Area of Science:
- Genomics
- Drug Discovery
- Bioinformatics
Background:
- Human gene sequencing has revealed numerous novel molecular targets for therapeutic drugs.
- The pharmaceutical industry requires advanced methods to identify and validate these targets.
- Technological advancements are essential to manage the increasing complexity of drug discovery.
Purpose of the Study:
- To review technological advancements in high-throughput methods for drug discovery.
- To discuss emerging fields like bioinformatics, cheminformatics, and functional genomics.
- To outline a critical path for future drug discovery processes.
Main Methods:
- Review of technological advances in biological and chemical assays.
- Analysis of the role of bioinformatics and cheminformatics in target identification.
- Exploration of functional genomics in validating molecular targets.
Main Results:
- High-throughput screening and validation methods are crucial for novel drug targets.
- Bioinformatics, cheminformatics, and functional genomics are essential components of modern drug discovery.
- A clear pathway for drug discovery into the new millennium has been established.
Conclusions:
- The integration of advanced technologies and interdisciplinary fields is transforming drug discovery.
- Efficient selection and validation of molecular targets are key to pharmaceutical innovation.
- A strategic roadmap is available for navigating the future of drug development.