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Related Experiment Videos

14-3-3 proteins: structure, function, and regulation.

H Fu1, R R Subramanian, S C Masters

  • 1Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. hfu@pharm.emory.edu

Annual Review of Pharmacology and Toxicology
|June 3, 2000
PubMed
Summary
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14-3-3 proteins regulate vital cell processes by binding diverse signaling molecules. This review explores their structural interactions, functions in cell signaling, and regulatory mechanisms.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • 14-3-3 proteins are conserved regulatory molecules found in all eukaryotic cells.
  • They interact with numerous signaling proteins, including kinases, phosphatases, and receptors.

Purpose of the Study:

  • To review the structural basis of 14-3-3 protein interactions with ligands.
  • To discuss the proposed functions of 14-3-3 proteins in various cell signaling pathways.
  • To explore emerging mechanisms regulating 14-3-3 protein activity.

Main Methods:

  • Literature review of structural and functional studies on 14-3-3 proteins.
  • Analysis of signaling pathways involving 14-3-3 protein interactions.
  • Examination of regulatory mechanisms controlling 14-3-3 protein function.

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Main Results:

  • 14-3-3 proteins bind a wide array of signaling proteins, influencing their activity.
  • These interactions are crucial for key cellular processes like signal transduction, apoptosis, and cell cycle control.
  • Structural insights reveal specific binding interfaces mediating 14-3-3-ligand interactions.

Conclusions:

  • 14-3-3 proteins are versatile regulators essential for eukaryotic cell function.
  • Understanding their interactions and regulation provides insights into cellular signaling networks.
  • Further research into regulatory mechanisms can reveal therapeutic targets.