Cyclodextrins in peptide and protein delivery

Area of Science:

• Pharmaceutical Sciences
• Biochemistry
• Drug Delivery Systems

Background:

• Cyclodextrins (CDs) are versatile cyclic oligosaccharides with a hydrophobic cavity and hydrophilic exterior.
• Their unique structure allows for the complexation of various guest molecules, including therapeutic agents.
• Challenges exist in formulating and delivering complex drugs like peptides, proteins, and oligonucleotides.

Purpose of the Study:

• To review recent advancements in using cyclodextrins (CDs) as carriers for therapeutic peptides, proteins, and oligonucleotides.
• To outline the in vitro interaction of CDs with cellular membranes as an indicator of bioadaptability.
• To discuss the diagnostic applications of CDs in serum cholesterol measurement.

Main Methods:

• Literature review of recent findings on cyclodextrin applications in drug delivery and diagnostics.
• Analysis of studies detailing cyclodextrin-membrane interactions in vitro.
• Examination of research on cyclodextrin-based cholesterol detection methods.

Main Results:

• CDs facilitate the development of advanced dosage forms for challenging therapeutic molecules.
• CDs demonstrate favorable interactions with cellular membranes, indicating potential for pharmaceutical use.
• CDs can differentiate and measure cholesterol in high-density and low-density lipoproteins based on surface recognition.

Conclusions:

• Cyclodextrins represent a promising excipient class for next-generation drug delivery systems.
• CDs offer a viable strategy for improving the formulation and delivery of peptides, proteins, and oligonucleotides.
• CDs possess significant potential in diagnostic applications, particularly for lipoprotein analysis.