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Related Experiment Videos

Cyclodextrin-based controlled drug release system.

Hirayama1, Uekama

  • 1Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-honmachi, Kumamoto 862-0973, Japan

Advanced Drug Delivery Reviews
|June 6, 2000
PubMed
Summary

Cyclodextrins (CDs) enhance drug delivery by forming inclusion complexes, improving drug properties and enabling targeted delivery. This review explores their advanced applications in pharmaceutical formulations and drug carriers.

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Cyclodextrins in peptide and protein delivery.

Advanced drug delivery reviews·2000

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Cyclodextrins (CDs) possess bioadaptability and multi-functional characteristics.
  • CDs alleviate undesirable drug properties via inclusion complex formation.
  • Natural and chemically modified CDs are utilized in advanced dosage forms.

Purpose of the Study:

  • To outline the current applications of cyclodextrins in advanced drug delivery systems.
  • To discuss the role of CDs in various routes of administration.
  • To address the advantages and limitations of CDs in drug delivery.

Main Methods:

  • Review of literature on cyclodextrin applications in drug delivery.
  • Analysis of cyclodextrin's role in oral drug delivery systems (immediate and delayed release).
  • Exploration of cyclodextrin conjugates for targeted drug delivery.

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Main Results:

  • Hydrophilic and ionizable CDs act as drug carriers in immediate and delayed release formulations.
  • Hydrophobic CDs can retard the release rate of water-soluble drugs.
  • CDs combined with other materials enhance drug formulation; CD-drug conjugates enable colon-targeting prodrugs.

Conclusions:

  • Cyclodextrins are versatile excipients for improving drug properties and delivery.
  • Advanced applications include enhanced oral delivery and targeted prodrug strategies.
  • Understanding CD limitations is crucial for effective drug formulation design.