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Pulsatile release from subcutaneous implants.

Medlicott1, Tucker

  • 1School of Pharmacy, University of Otago, P.O. Box 913, Dunedin, New Zealand

Advanced Drug Delivery Reviews
|June 6, 2000
PubMed
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Subcutaneous implants can deliver antigens and hormones in pulses for animal production and veterinary medicine. This review covers formulation strategies for single-shot vaccines and hormone therapies mimicking natural secretion patterns.

Area of Science:

  • Biomedical Engineering
  • Veterinary Pharmacology
  • Drug Delivery Systems

Background:

  • Subcutaneous implants offer potential for controlled release of bioactive compounds.
  • Pulsatile delivery systems are desirable for specific applications in animal health and production.

Purpose of the Study:

  • To review formulation approaches for subcutaneous implants exhibiting pulsatile release.
  • To highlight potential applications in single-shot vaccines and hormone replacement therapy.

Main Methods:

  • Review of existing literature on subcutaneous implant formulations.
  • Analysis of strategies to achieve pulsatile drug release profiles.

Main Results:

  • Various formulation techniques can yield pulsatile release from subcutaneous implants.

Related Experiment Videos

  • Potential for single-administration vaccines and hormone therapies with natural secretion patterns.

    • Conclusions:

    • Subcutaneous implants with pulsatile release are feasible and beneficial for animal production and veterinary medicine.
    • Formulation science is key to achieving desired release kinetics for vaccines and hormones.