Related Experiment Videos
Detection of the interleukin 18 family in rat brain by RT-PCR
R D Wheeler1, A C Culhane, M D Hall
1School of Biological Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, M13 9PT, Manchester, UK.
Brain Research. Molecular Brain Research
|June 6, 2000
Abstract:
Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL-18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR.