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Microsatellite instability in thyroid papillary carcinoma and multinodular hyperplasia

T Dobosz1, T Lukienczuk, M Sasiadek

  • 1Department of Forensic Medicine, Wroclaw Medical University, Wroclaw, Poland.

Oncology
|June 6, 2000
PubMed

Insights

Microsatellite instability (MSI) and loss of heterozygosity (LOH) were investigated in thyroid tumors. Both alterations were found in papillary carcinomas and multinodular hyperplasias, with higher rates in carcinomas.

Area of Science:

  • Molecular biology
  • Oncology
  • Genetics

Background:

  • Microsatellite instability (MSI) results from DNA mismatch repair gene mutations.
  • Impaired DNA repair contributes to cancer development and progression.
  • Limited research exists on MSI in thyroid tumors.

Purpose of the Study:

  • To investigate microsatellite instability (MSI) as a potential characteristic of thyroid tumors.
  • To analyze MSI and loss of heterozygosity (LOH) in papillary thyroid carcinomas and multinodular hyperplasias.

Main Methods:

  • Analysis of 12 papillary thyroid carcinomas and 17 multinodular hyperplasias.
  • Examination of 13 microsatellite loci for MSI and LOH.

Main Results:

  • MSI and LOH were detected in both papillary thyroid carcinomas (65% of cases) and multinodular hyperplasias (35% of cases).
  • Loss of heterozygosity (LOH) was more frequent than MSI in carcinomas.
  • The LOH/MSI ratio was nearly equal in multinodular hyperplasias.

Conclusions:

  • MSI and LOH are present in thyroid lesions, suggesting a role in thyroid tumorigenesis.
  • Papillary thyroid carcinomas exhibit a higher frequency of these molecular alterations compared to multinodular hyperplasias.

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