Related Experiment Video
Updated: Aug 10, 2026

07:51
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Perceptual reactance, drug preference, and electrodermal activity in treatment-seeking substance abusers
1UCLA School of Nursing, Acute Care Section 90095-6918, USA. pcompton@sonnet.ucla.edu
Issues in Mental Health Nursing
|June 6, 2000
Summary
Perceptual reactance (PR) influences drug choice in substance abusers. Individuals with lower PR may prefer stimulants, while those with higher PR may prefer depressants, but this was only seen in responsive participants.
Area of Science:
- Neuroscience
- Psychology
- Addiction Research
Background:
- Perceptual reactance (PR) involves modulating sensory stimuli.
- PR may influence substance abuse and drug preference.
- An adaptive model suggests varying drug preferences based on PR levels.
Purpose of the Study:
- To investigate perceptual reactance as a factor in drug abuse.
- To test the hypothesis that drug preference correlates with PR.
- To differentiate between perceptual reducers and augmenters in substance abusers.
Main Methods:
- Assessed PR using the Reducing-Augmenting Scale (subjective) and electrodermal responses (objective).
- Studied 122 treatment-seeking substance abusers, stratified by abstinence.
- Examined the relationship between PR measures and drug preference (stimulants vs. opioids/sedatives).
Main Results:
- The hypothesis was supported only in the electrodermally-responsive subgroup.
- A high rate of electrodermal non-responsivity was observed in the sample.
- Perceptual reducers showed a preference for experience-expanding drugs, and augmenters for sensory-restricting drugs, within the responsive group.
Conclusions:
- Perceptual reactance may play a role in drug preference, but its effect is contingent on physiological responsiveness.
- Electrodermal non-responsivity is a notable finding requiring further investigation in substance abuse populations.
- PR-based drug preference models may need refinement to account for individual differences in sensory processing and responsiveness.
Related Concept Videos
Drug Dependence
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Drugs Affecting Neurotransmitter Release or Uptake
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
Drug Abuse and Addiction: Pharmacological Phenomena
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Substance Use Disorders Affecting Sleep
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...

