Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Rheumatic disorders. Overview].

B Fautrel1, P Bourgeois

  • 1Service de Rhumatologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

Drugs
|June 7, 2000
PubMed
Summary
This summary is machine-generated.

Osteoarthritis (OA) and rheumatoid arthritis (RA) share inflammatory pathways causing cartilage destruction and significant healthcare costs. Effective treatments must balance symptom control, disease progression, and drug safety for patients with these common rheumatic diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does ICG have Time-Dependent Effects on the Lymphatic System in Women after Breast Cancer Surgery?

Lymphology·2025
Same author

Greater pain and functional impairment in chronic erosive hand osteoarthritis compared to treated rheumatoid arthritis: A comparative study.

Osteoarthritis and cartilage open·2025
Same author

Global health in axial spondyloarthritis: thresholds for the Assessment of SpondyloArthritis international Society Health Index and the EuroQol score: analysis of the ASAS-PerSpA study.

Scandinavian journal of rheumatology·2024
Same author

Validation, implementation and quality control of a Torque Teno Virus qPCR in a multinational clinical trial.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2024
Same author

[Case report of a cystic lung disease: From a rarity to the discovery of an unknown genetic variant].

Revue des maladies respiratoires·2024
Same author

Manual Lymphatic Drainage Increases the Number of Opened Lymphatic Pathways in Patients with Lower Limb Lymphedemas: A Sequential Research on 80 Patients.

Lymphology·2023
Same journal

Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

Drugs·2026
Same journal

Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

Drugs·2026
Same journal

Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

Drugs·2026
Same journal

Relacorilant: First Approval.

Drugs·2026
Same journal

Developmental Progress and Future Potential for Inhaled Biologics in the Treatment of Respiratory Diseases.

Drugs·2026
Same journal

Linerixibat: First Approval.

Drugs·2026
See all related articles

Area of Science:

  • Rheumatology
  • Immunology
  • Biochemistry

Context:

  • Osteoarthritis (OA) and rheumatoid arthritis (RA) are prevalent rheumatic diseases with distinct pathophysiologies.
  • Both conditions involve cartilage destruction and impose substantial economic burdens on healthcare systems.
  • Despite differences, shared inflammatory pathways and key molecules like interleukin-1 and tumor necrosis factor-alpha are implicated in both OA and RA.

Purpose:

  • To explore the commonalities and differences in the inflammatory processes of OA and RA.
  • To highlight the role of inflammation in metalloproteinase synthesis and cartilage degradation in both diseases.
  • To underscore the public health and economic impact of these prevalent rheumatic conditions.

Summary:

  • Inflammatory processes, though varying in intensity, contribute to cartilage destruction in both OA and RA via metalloproteinases and free oxygen radicals.

Related Experiment Videos

  • Both diseases incur significant direct and indirect healthcare costs, with OA posing a greater challenge due to its higher prevalence.
  • Identifying optimal therapeutic strategies is crucial for managing symptoms, slowing disease progression, and maintaining patient activity while prioritizing drug safety.

    • Impact:

    • Understanding shared inflammatory pathways can inform the development of novel therapeutic targets for both OA and RA.
    • Effective management strategies are needed to mitigate the substantial socioeconomic impact of these widespread rheumatic diseases.
    • The research emphasizes the critical need for therapeutic approaches that enhance efficacy without compromising patient safety.