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Tuberculosis in chronic renal failure in Jeddah
1Department of Medicine, King Khalid National Guard Hospital, Jeddah, King of Saudi Arabia.
The Journal of Infection
|June 7, 2000
Summary
Patients with chronic renal failure face a high risk of developing tuberculosis. Early screening and considering tuberculosis chemoprophylaxis are crucial, especially for those on haemodialysis in high-incidence regions.
Area of Science:
- Nephrology
- Infectious Diseases
- Public Health
Background:
- Patients with chronic renal failure (CRF) are at increased risk of tuberculosis (TB).
- This risk is particularly noted in individuals undergoing haemodialysis.
- Understanding TB incidence in pre-dialysis CRF patients is vital for early intervention.
Purpose of the Study:
- To monitor tuberculosis development in non-dialyzed patients with CRF.
- To assess TB incidence in patients presenting at a renal clinic in Saudi Arabia.
Main Methods:
- A 3-year prospective study followed 80 CRF patients.
- Regular monitoring included Mantoux tests, chest radiographs, and sputum examinations every 6 months.
Main Results:
- 10% (8/80) of CRF patients developed tuberculosis within 3 years.
- Tuberculosis occurred in patients with lower creatinine clearances, irrespective of underlying renal disease.
- Manifestations included pulmonary, renal, cervical lymphadenitis, and tuberculous meningitis.
Conclusions:
- Routine tuberculosis screening is recommended for CRF patients in renal units.
- Tuberculosis chemoprophylaxis should be considered for haemodialysis patients, particularly in high TB incidence areas.