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Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist
M Murakami1, O Nakagawasai, S Fujii
1Department of Molecular Pharmacology, Tohoku University School of Medicine, Seiryomachi, Aobaku, 980-8575, Sendai, Japan. mmura@mail.cc.tohoku.ac.jp
Brain Research
|June 8, 2000
Abstract:
We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons.